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By train

Alsace has 5 TGV train stations: Saverne, Strasbourg, Sélestat, Colmar and Mulhouse.

Estimated travel times

Departure Travel time to Strasbourg by TGV
Metz/Nancy (Lorraine TGV) 0:46
Reims (Champagne-Ardennes TGV) 1:26
Paris - Gare de l'Est 1:56
Charles de Gaulle Airport 1:57
Lille 2:57
Rennes 4:54
Nantes 5:19
Bordeaux 5:17
Stuttgart 1:21
Frankfort 1:51
Munich 3:46
Departure Travel time to Mulhouse by TGV
Paris - Gare de Lyon 2:41
Lille 4:12
Lyon 2:45
Charles de Gaulle Airport 3:15
Marseille 4:41
Montpellier 4:49
Zurich 1:19

More: 
oui.sncf/en
www.ter.sncf.com/grand-est
www.railteam.eu
www.raileurope.com
(
non exhaustive list)